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Vascular Health. 
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Joined: Mon Aug 18, 2008 9:58 am
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Post Vascular Health.
As a first step toward optimal healthy longevity in the progress toward immortality we know that those genetically fortunate individuals with 'longevity syndrome' have a clear vascular system and do not develop atherosclerosis due to either high HDL-cholesterol levels or low LDL-cholesterol levels. Thus it is important to start now and adjust blood lipid values to approximate those found naturally in those with 'longevity syndrome'. There are wonders ahead with molecules to double HDL-cholesterol levels and sirtuins to mimic the life extension effects of 'famine syndrome' already in clinical trials. We are on the verge of an astonishing era.

I'm pleased I found this web site and do intend to return to communicate with like minded individuals.

Read about adjusting blood lipid values on my web page at: http://www.erinpharm.org/erinpharm_central.html

Sean Fahey


Mon Aug 18, 2008 10:13 am
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Joined: Sun Aug 10, 2008 1:49 pm
Posts: 5
Post Re: Vascular Health.
Hello Sean!

I've read your article with great interest cause I'm also interested in life extension and Vascular Health is one of the most important things.
Please tell me which method you personally consider is the best to lowering blood cholesterol?

Thanks,
John.


Tue Aug 19, 2008 3:57 am
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Post Re: Vascular Health.
Hello John,

I use the statin Zocor (simvastatin) and have lowered my LDL-cholesterol to around 40 mg/dL with 40 mg/day. I take 200 mg Coenzyme Q10 ubiquinol to compensate for the statin's reduction of Coenzyme Q10 production. I prefer Zocor to other statins because of its known ability to penetrate the blood-brain barrier and recent evidence that it benefits cognitive function (see my Gazette below). I also take 4 capsules of omega-3 fish oils a day (EPA/DHA 350 mg/250 mg each). These keep my triglyceride level at about a comfortable 120 mg/dL while in combination with the Zocor have brought my C-reactive protein level down below 0.10 mg/L - thus very cardioprotective against heart attack and stroke. I of course also have a diet rich in vegetables and drink diluted pomegranate juice as my regular drink of choice making sure I take at least 8 ounces of juice a day. I'm currently working on raising my HDL-cholesterol with exercise, gamma E tocopherols to raise my apolipoprotein A level (I was low) and am considering taking fenofibrate. These of course are just a 'holding pattern' until a CETP inhibitor reaches approval. Merck's anacetrapib looks to be the closest, possibly within two years, and early clinical data indicates it can raise HDL-cholesterol by more than 100%. So by 2010 I hope to be on my own personal anti-agathics of Zocor and Anacetrapib - chuckle - reminiscent of the James Blish book Cities in Flight!

http://www.erinpharm.org/Gazette_July_2008.html
http://www.erinpharm.org/Gazette_June_2008.html

Regards

Sean Fahey


Tue Aug 19, 2008 6:48 am
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Joined: Mon Aug 18, 2008 9:58 am
Posts: 7
Post Re: Vascular Health.
Hi fellow members,

I'm pleased to see that we've passed the 20 member point. Let's all start thinking of ways to build membership. I'd be interested in the implications for society when increasing numbers of people are as healthy in their post 65 years as when they were in their 30s and 40s ... re people attempting to reenter the work force against entrenched attitudes trying to stop them. Do we have a social scientist on board to think about this topic, maybe write an essay?

As for myself...latest blood tests...total cholesterol down to 106 mg/dL, LDL-cholesterol down to 44 mg/dL, C-reactive protein below 0.10 mg/L. Getting near those 'longevity syndrome levels'! Feeling fine and healthy. Still thinking of beginning fenofibrate to raise HDL-cholesterol. Has anyone any experience of adding fenofibrate to a statin?

Sean Fahey


Mon Sep 08, 2008 8:52 am
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Joined: Sun Jul 20, 2008 10:48 am
Posts: 7
Post Re: Vascular Health.
Hello Sean!

Thank you for your help! Yes we've passed 20 member point. But the discussion process is still very slow. We plan to invite several specialists in different areas: social science, medicine, history, philosophy…
We are going to build the solid theory or lifestyle with the final aim – Physical Immortality.
Concerning your question about fenofibrate – I don’t use any kind of medicine (may be cause I’m young :D ). Your blood test results are amazing!

Congratulations and good luck in your activities!

_________________
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Tue Sep 09, 2008 6:37 am
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Joined: Sun Aug 10, 2008 1:49 pm
Posts: 5
Post Re: Vascular Health.
Sean Fahey wrote:
Hi fellow members,

I'm pleased to see that we've passed the 20 member point. Let's all start thinking of ways to build membership. I'd be interested in the implications for society when increasing numbers of people are as healthy in their post 65 years as when they were in their 30s and 40s ... re people attempting to reenter the work force against entrenched attitudes trying to stop them. Do we have a social scientist on board to think about this topic, maybe write an essay?

As for myself...latest blood tests...total cholesterol down to 106 mg/dL, LDL-cholesterol down to 44 mg/dL, C-reactive protein below 0.10 mg/L. Getting near those 'longevity syndrome levels'! Feeling fine and healthy. Still thinking of beginning fenofibrate to raise HDL-cholesterol. Has anyone any experience of adding fenofibrate to a statin?

Sean Fahey


Hello Sean. Your results are amazing!

Please advise what other activities (except "Vascular Health") can you suggest to improve the health?

Thanks!


Wed Sep 17, 2008 6:17 am
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Joined: Mon Aug 18, 2008 9:58 am
Posts: 7
Post Re: Vascular Health.
Another step forward for vascular health occurred December 15, 2008, when the FDA approved Trilipix for use with a statin. Published data indicates that the combination will raise HDL-cholesterol levels by 20% and lower triglycerides by 40% as well as the expected significant lowering of LDL-cholesterol. This is most significant for men with HDL-cholesterol <40mg/dL. I've provided hyperlinks in my Erinpharm december gazette for those who wish to read further. I continue my focus on means to mimic the longevity syndrome blood lipid levels of genetically fortunate centenarians and centenarian teens. One step at a time to a very long life! Let's all live long enough through to dramatic progress in life extension!

Sean Fahey

Good health to all in 2009.


Sat Jan 03, 2009 7:54 am
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Joined: Mon Aug 18, 2008 9:58 am
Posts: 7
Post Re: Vascular Health.
Hello Fellow members,

Good news this week on the medical research frontier relating to vascular health. Merck has announced that its experimental drug anacetrapib in the latest clinical trial raised HDL-cholesterol from 41mg/dL to 101mg/dL while also significantly reducing LDL-cholesterol in >1,600 study patients. It was significant that in this small study there were fewer heart attacks, strokes, and invasive procedures for blocked arteries in study patients taking anacetrapib. Merck is now planning to begin a 30,000 patient study by April of 2011. If the larger study confirms what is already proven then a possible FDA filing could be by 2015.

For those of you following my personal quest for optimal healthy longevity you will realise that a combination of anacetrapib with a statin will reproduce the two known longevity syndromes in which centenarian teens have been shown to have either very high HDL-cholesterol or very low LDL-cholesterol. It is believed such centenarian teens enjoy their extended lives healthy and cognitively intact because they never develop atherosclerosis and their vascular systems remain clear and free of plaque.

As for myself I continue to follow my own advice I outline on my ErinPharm Central page. I'm maintaining my LDL-cholesterol below 50 mg/dL along with the rest of my regimen and am enjoying a slow but steady increase in my mobility as well as physical exercise capacity. Step by step, year by year, I'm aiming at having both those longevity syndromes and getting rid of my atherosclerosis completely. I'll be 67 in March 2011 and my confidence in reaching that objective is even stronger than ever.

Optimal healthy longevity is the initial step to seeking a practical physical long life, a life long enough that medical research brings us the wonder of reversing the cellular damage due to ageing and extended healthy longevity becomes not a dream but a real prospect.

John Fahey

http://www.erinpharm.org/erinpharm_central.html
http://www.erinpharm.org


Thu Nov 18, 2010 4:49 am
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